| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-141 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-545 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate |
1987-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_123041deaa94aa9167a93ac344acbdd3 |
| publicationDate |
1987-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
FR-2595714-A1 |
| titleOfInvention |
IMPROVED PROCESS FOR PRODUCING INTERLEUKIN-1 |
| abstract |
A MICROBIALLY PRODUCED HUMAN INTERLEUKIN-1 ESSENTIALLY ENDOTOXIN-FREE, IN THE FORM OF A SUBSTANTIALLY HOMOGENEOUS PROTEIN AND HAVING A SPECIFIC ACTIVITY OF AT LEAST ABOUT 5-10 UNITS PER MG, AND A METHOD FOR THEIR PREPARATION AND APPLICATION OF HUMAN INTERLEUKIN-1 AS A PHARMACEUTICAL AGENT. THE METHOD COMPRISES DISRUPTING MICROBIAL CELLS WHICH HAVE BEEN TRANSFORMED WITH AN EXPRESSION VECTOR CONTAINING A GENE FOR RECOMBINANT HUMAN INTERLEUKIN-1, AND INDUCED TO EXPRESS SUCH GENE, AND SEPARATE INSOLUBLE CELLULAR MATERIALS FROM THE CYTOSOL FRACTION AND ISOLATION OF HUMAN INTERLEUKIN-1 FROM SAID CYTOSOL FRACTION BY GEL FILTRATION FOLLOWED BY ION EXCHANGE CHROMATOGRAPHY. |
| priorityDate |
1986-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |