| abstract |
THE OBJECT OF THE INVENTION GENERALLY IS THE APPLICATION OF APYRIMIDIC ACIDS TO THE CONSTITUTION OF PROBES OR MORE GENERALLY OF SEQUENCES USED FOR THE DETECTION AND, IF APPLICABLE, FOR THE SEPARATION OF NUCLEOTIDIC SEQUENCES OF COMPLEMENTARY NUCLEIC ACIDS CONTAINED IN A MEDIUM , BY HYBRIDATION OF SAID APYRIMIDIC ACIDS WITH SAID NUCLEOTIDIC SEQUENCES. IT IS MORE PARTICULARLY TARGET TO NUCLEIC ACIDS, IN PARTICULAR MODIFIED DNA, IN WHICH AT LEAST PART OF THE DESOXYCITYDINE-PHOSPHATE OR THYMIDINE-PHOSPHATE GROUPS, IN PARTICULAR, IS REPLACED BY GROUPS (CF DRAWING IN BOPI) LINKED TO THE GROUP OR GROUPS INTACT NUCLEOTIDES, R REPRESENTING A COUPLING GROUP. |