abstract |
METHODS FOR THE PREPARATION OF NEW AMINO-3-TRIDESOXY-3,4,6-GLYCALS AND USE OF THESE NEW COMPOUNDS FOR THE PREPARATION OF ANTHRACYCLINS. THE NEW GLYCALS, OF GENERAL FORMULAS BELOW, ARE PREPARED BY PROCESSING GLYCALS OF FORMULAS 10 AND 11 WITH A MIXTURE OF SODIUM HYDRIDE AND CARBON SULPHIDE, THEN METHYL IODIDE, TO OBTAIN METHYLTHIOCARBONATES OF FORMULA GENERALS 12 AND 13 IN WHICH METHYL-THIOCARBONATE GROUPS ARE ELIMINATED BY REDUCTION BY TRIBUTYLETAIN HYDRIDE IN THE PRESENCE OF AZO-BIS-ISOBUTYRONITRILE. APPLICATIONS: USE OF GLYCALS OF FORMULAS 14 AND 15 FOR THE PREPARATION OF ANTHRACYCLINS; USE OF THESE LATEST FOR THE PREPARATION OF MEDICINES. |