| abstract |
THE IMMUNOTOXIN ACCORDING TO THE INVENTION ESSENTIALLY CONSISTS OF AN ANTIBODY, PREFERRED MONOCLONAL, SPECIFIC TO GLOBOTRIAOSYLCERAMIDE, OR CERAMIDETRIHEXOSYL, OF STRUCTURE: GALA (14) GALB (14) GLCB (11) WITH CERAMIDE, OR ANTIOCGENE WITH CTH, OR ANTIOCGENE CONDITIONS ALLOWING THE INTERNALIZATION OF THE TOXIN IN ANIMAL CELLS. THIS IMMUNOTOXIN CAN BE USED BOTH IN VITRO AND IN VIVO FOR THE DESTRUCTION OF MALIGNANT CELLS CARRYING THE CTH ANTIGEN, EVEN IN QUANTITIES NOT DETRICABLE BY KNOWN PRECISE METHODS OF ANALYSIS. |