abstract |
A PROCESS FOR RESOLVING A RACEMIC MIXTURE OF B-ADRENERGIC ARYL- OR HETARYL-OXYPROPANOLAMINES SUCH AS () -2-2-HYDROXY-3-2- (1H-INDOL-3-YL) -1.1 - DIMETHYLAMINOPROPOXYBENZONITRILE IN ITS INDIVIDUAL ENANTIOMERS. THE PROCESS CONSISTS OF CONVERTING THE RACEMIC INTO A PAIR OF DIASTEROMERIC UREA DERIVATIVES BY REACTION WITH AN ARALKYLISOCYANATE, IN SEPARATING THE MIXTURE OBTAINED IN ITS INDIVIDUAL DIASTEROMERS AND IN EASY REGENERATING THE AMINE OF THE INTERMEDIATE LURE BY CLIVID. 'HYDRAZINE HELP. THE FINAL STAGE IS IMPROVED BY THE ADDITION OF AN A-KETO-CARBOXYLIC ACID SUCH AS PYRUVIC ACID. PHARMACOLOGICAL APPLICATION OF THESE COMPOUNDS. |