Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53dff29241864c5dc0eeca3fcbe40674 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08 |
filingDate |
1982-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f20c16dbd9c7b3742f3e00d8ffeef004 |
publicationDate |
1983-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
FR-2515184-A1 |
titleOfInvention |
SYNTHESES OF CODEINE DERIVATIVES AND OTHER 3-O-ALKYLMORPHINS AND INTERMEDIATE COMPOUNDS USED THEREOF |
abstract |
THE INVENTION CONCERNS THE SYNTHESIS OF DERIVATIVES OF CODEINE AND OTHER 3-0-ALKYLMORPHINES. A 14-OH GROUP IS INTRODUCED INTO A MORPHINANE BY REACTION OF SINGLE OXYGEN WITH A NEW DIENOL-ESTER OF A N-SUBSTITUENT-3-O-ALKYLNORMORPHINONE. THE COMPOUND OBTAINED IS ALSO A NEW COMPOUND WHICH CAN BE TRANSFORMED INTO NOROXYMORPHONE BY SUCCESSIVE OPERATIONS OF CATALYTIC HYDROGENATION, HYDROLYTIC REMOVAL OF THE SUBSTITUTE OF NITROGEN AND HYDROLYSIS AND O-DEALKYLATION. THE INTERMEDIATE DIENOL ESTER IS PREPARED BY N-DEMETHYLATION OF CODEINE OR ANOTHER 3-O-ALKYLMORPHINE FOLLOWED BY OXIDATION AND ESTERIFICATION OF THE OXIDIZED PRODUCT WITH AN ANHYDRIDE OR AN ACID HALOGENIDE . 14-HYDROXYMORPHINANS ARE STRONG ANALGESICS AND ANTAGONISTS OF NARCOTICS. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9546177-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2829541-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2564838-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0158476-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0159823-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2562072-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0164290-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2566777-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4639520-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5112975-A |
priorityDate |
1981-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |