| abstract |
THE INVENTION CONCERNS NEW AMIDINE COMPOUNDS RESPONDING TO FORMULA I (CF DRAWING IN BOPI) AND THEIR ADDITIONAL SALTS WITH PHARMACEUTICALLY ACCEPTABLE ACIDS. THESE COMPOUNDS ARE USEFUL AS POWERFUL ANTI-TRYPSIN, ANTI-PLAMIN, ANTI-KALLIKREINE, ANTI-THROMBIN, AS WELL AS ANTI-COMPLEMENT AGENTS BECAUSE OF THEIR STRONG ANTI-CL (CLR, CLS) AND ANTI-COMPLEMENT ACTIVITY. THESE COMPOUNDS ARE PREPARED BY ESTERIFICATION OF A CARBOXYLIC ACID RESPONDING TO FORMULA IIR-COOH (II) WITH A 4-B-AMIDINOETHENYL) PHENOL RESPONDING TO FORMULA III (CF DRAWING IN BOPI) AND THEY CAN BE TRANSFORMED IF NECESSARY INTO THEM ADDITIONAL SALTS WITH PHARMACEUTICALLY ACCEPTABLE ACIDS. |