| abstract |
Compound of formula: (CF DRAWING IN BOPI) in which R1 is a hydrogen atom, an alkyl, aryl or arylalkyl radical, a hydrolyzable acyl protecting group, or a group of formula: (CF DRAWING IN BOPI) R2 is an atom hydrogen or an alkyl, trifluoromethyl or pentafluorethyl radical; R3 is -CH2-, -S-, -CH (OH) -, -CH (O-alkyl) -, -CH (O-aryl) -, -CH (S-alkyl) -, -CH (S-aryl ) -, -C (O-alkyl) 2-, -C (S-alkyl) 2-, (CF DRAWING IN BOPI) -CC12-, -CF2-, -CHC1-, or -CHF-, and R4 is - CH2- or -S-, with the proviso that if R4 is -S-, R3 is -CH2-; or else, taken together, R3 and R4 form a group of formula -CH = CH-; and n is equal to 0.1 or 2. These compounds inhibit the transformation of angiotensin I into angiotensin II in mammals and therefore can be used for the treatment of hypertension. |