| abstract |
THE INVENTION CONCERNS THE PHARMACEUTICAL INDUSTRY. ITS SUBJECT TO NEW VITAMIN D DERIVATIVES, KNOWING 24,24-DIFLUORO-1A, 25-DIHYDROXYCHOLECALCIFEROL AND 24,24-DIFLUORO-1A, 25-DI-HYDROXY-5,6-TRANS-CHOLECALCIFEROL. THESE COMPOUNDS HAVE A VITAMINOID D ACTIVITY SENSITIVELY EQUIVALENT TO THAT OF 1A, 25-DIHYDROXYCHOLECALCIFEROL, AS SHOWED BY THEIR ABILITY TO INCREASE THE INTESTINAL TRANSPORT OF CALCIUM, TO INCREASE THE LEVEL OF SERUM CALCIUM AND TO PREVENT RACH. THESE COMPOUNDS ARE PREFERRED FOR REPLACING VITAMIN D IN THE TREATMENT OF CONDITIONS ACCOMPANIED BY DISTURBANCES OF CALCIUM AND PHOSPHORUS METABOLISM. |