| abstract |
PREPARATION OF NEW AMIDOXIMIC COMPOUNDS OF FORMULA: IN WHICH EACH R TAKEN SEPARATELY REPRESENTS A METHYL OR AN ETHYL, OR BOTH R TAKEN TOGETHER FORM AN ETHYLENE GROUP WHICH IS SUBSTITUTED BY A METHYL. B-AMINOCROTONONITRILE IS HYDROLYZED IN AN ACIDIC MEDIUM, ACETOACETONITRILE OBTAINED TO REACT WITH A TRIALKYL ORTHOFORMIATE OR AN ETHYLENE GLYCOL DERIVE TO PRODUCE THE CORRESPONDING ACETAL, WHICH IS THEN TREATED BY POLAR SOLVENCE AND THEN TREATED BY SOLVENCE 'AN ALKALINE SUBSTANCE, BY HYDROXYLAMINE. THESE NEW COMPOUNDS GIVE SELECTIVELY AND WITH GOOD PERFORMANCE, BY CYCLING IN AN ACIDIC MEDIUM, AMINO-3 METHYL-5 ISOXAZOLE, USED AS AN INTERMEDIATE PRODUCT FOR THE MANUFACTURE OF MEDICINES, IN PARTICULAR SULFONAMIDES. |