http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2406632-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e6c80a50846f752716f524cff4632c5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-24 |
| filingDate | 1978-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1979-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2406632-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF A 7-CHLORO-5- (2-CHLOROPHENYL) -BENZODIAZEPINONE |
| abstract | 7-Chloro-5- (2-chlorophenyl) -1,3-dihydro-2H-1,4-benzodiazepin-2-one is prepared from 2 ', 5-dichloro-2-aminobenzophenone, phthalimidoglycine and d hydrazine in a single pass and in a single reaction medium, without separation of intermediates. A suspension of phthalimidoglycine in chloroform is heated to reflux with thionyl chloride and the clear solution obtained is added, first of 2 ', 5-dichloro-2-amino-benzophenone, then of ethanol and hydrazine, the 2,5-dichloro-2-aminobenzophenone / chloroform / ethanol weight ratio being 1: 15-16: 4-5, the molar ratio of 2 ', 5-dichloro-2-amino-benzophenone to hydrazine being equal to approximately 1: 2 and the reaction temperature being room temperature. The compound thus prepared is a drug which acts on the central nervous system, on which it manifests truly exceptional activity, both as an anxiolytic and as a hypnotic; in addition, it has found wide use in the neuro-psychiatric field, in the treatment of psychotic symptomatology of moderate severity. |
| priorityDate | 1977-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.