http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2377397-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d669af06cb2abbcd6823699582a97002 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-382 |
| filingDate | 1978-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2377397-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF (1,1-DITHIENYL- (3) -1-HYDROXYPROPYL- (3)) - (1-PHENYL-1-HYDROXYPROPYL- (2)) - AMINE AND (1,1-DITHIENYL- ( 3) -PROPEN- (1) -YL- (3)) - (1-PHENYL-PROPYL- (2)) - AMINE |
| abstract | Øl, l-dithienyl- (3) - 1-hydroxypropyl- (3) õ-Ø1-phenyl-1-hydroxypropyl- (2) õ-amine (formula I) is prepared by condensing, in an inert medium, at a temperature below - 50 degrees C, a lithium-thienyl- (3) with an alkyl ester of beta -halogeno-propionic acid of formula (II, then reacting the compound obtained, of formula (III), with the 2 -amino-1-phenyl-propanol- (1), in an inert medium and in the presence of a basic compound. The reaction product of formula I obtained is dehydrated to obtain Ø1,1-dithienyl- (3) -propen - (1) -yl- (3) õ-Ø1-phenyl-propyl- (2) õ-amine. The compound of formula I possesses valuable pharmacodynamic activities. In addition, it is an important intermediate for the preparation. Ø1,1-dithienyl- (2) -propen- (1) -yl- (3) õ-Ø1-phenyl-1-hydroxypropyl- (2) õ-amine which also has a strong pharmacodynamic activity. |
| priorityDate | 1977-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.