| abstract |
The compounds of the formula I in which R1, R2, R3 and X have the meaning stated in Claim 1 are prepared by condensation of a 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine with an alkyl isocyanate or isothiocyanate or with a substituted S-methylthiourea. The condensation expediently takes place in a solvent at the reflux temperature. The products can be isolated by crystallisation as free bases or as pharmaceutically acceptable acid addition salts. The compounds of the formula I show pharmacological inhibitory effects on ulcers, especially gastric and intestinal ulcers, and on gastric secretion. |