abstract |
New 4-hydroxy quinolines are of formula (I):- In (I) R1 is 8-C, and R3 is 2-thiazolyl; R1 is 7-CF3 and R3 is 2-thiazolyl; R1 is 7-Cl and R3 is 2- thiazolyl; R1 is 8-CF3 and R3 is 2- oxazolyl; or R1 is 8-CF3 and R3 is 2-thiazolyl). A typical cpd. is 4-hydroxy-8-chloro-N-(2-thiazolyl) 3-quinoline carboxamide. This was prepd. by reaction of 7 g. 4-hydroxy-8-chloro-3-quinoline carboxylic acid chloride and 2.9 g. 2-amino thiazole in pyridine at ambient temperature. The yield was 6.5 g., m.pt. >369 degrees C. |