http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2311542-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_99c28bf1df902d985d9a6165cfd7c642 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 |
| filingDate | 1975-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88d16e901ebfb3c9e1b360a0b901478e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b09b55f43309f812d699acd9619b07c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_550a222df5cd2f3da39b1989dd1c0e23 |
| publicationDate | 1976-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2311542-A1 |
| titleOfInvention | ALLYL-1 (DICYCLOHEXYL-2,2 ETHYL) -2 PIPERIDINE FOR USE AS A MEDICINAL PRODUCT |
| abstract | 1-Allyl-2-(2,2-dicyclohexylethyl)piperidine and its acid-addition salts are new. Cpds. have Coronary vasodilator and spasmolytic activity. 1-Allyl-2-(2,2-dicyclohexylethyl) piperidine is prepd. by reaction of allyl bromide with 2-(2,2-dicyclohexylethyl)piperidine in benzene in presence of K2CO3 at reflux temp. for 60 h. In the isolated heart of the rabbit a concn. of 0.001 mg/ml increased the coronary flow by 54% for 15 min. 0.003 mg/ml by 77% for 11 min. and 0.01 mg/ml by 126% for >15 min. A dose of 3 mg/kg i.v. was tolerated by the rabbit, any cardiac effects being reversible. Doses is 120-3000 mg/day orally. |
| priorityDate | 1975-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.