http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2303018-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8dca81337699f0cf596f48073268cacc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 |
| filingDate | 1974-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2303018-A1 |
| titleOfInvention | METHOD FOR THE PREPARATION OF AMPICILLIN |
| abstract | Prepn. of ampicillin is new by converting the 9-anthryl methyl ester of a natural penicillin e.g. benzylpenicillin, into the 9-anthrylmethyl ester of ampicillin. This ester is hydrolysed with an acid (trichloroacetic acid) or a base (alkylmercaptan Na salt). The 9-anthrylmethyl esters of benzyl penicillin and ampicillin are new. The use of 6-APA is avoided. The ester group protects the beta-lactam ring and is readily removed. Penicillins G or V are converted into their 9-anthrylmethyl esters, then into the iminohalides and iminoethers. The latter react with reactive derivs of phenylglycine to give the 9-anthrylmethyl ester of ampicillin. Hydrolysis gives ampicillin. |
| priorityDate | 1974-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.