abstract |
Drugs contg amino or amido gps (esp. dimethofrine (I) or insulin) are reacted with a polysaccharide (esp. dextran) to form a bond between the amino or amido gp and the hydroxy gp. Thus (I) is treated with CNBr chromato graphed over 'Sephadex' (RTM) G25 to removed CNBr and the eluate added to (I). The product is m.wt 90,000, is purified by chromatography over 'Sephadex' G-50. |