http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2223364-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c53efaf4a04116082d33f1319dddfe5a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J- |
| filingDate | 1973-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2223364-A1 |
| titleOfInvention | Fluorometholone preparation - by four-stage process from 9-alphafluoro-11, 17-dihydroxy-progesterone |
| abstract | Prepn of fluorometholone (6alpha-methyl-9alpha-fluro-11beta, 17alpha-dihydroxypregna-1,4-diene-3,20-dione) by treating 9alpha-fluoro-11beta, 17alpha-dihydroxyprogesterone with methyl or ethyl orthoformate in presence of an acid catalyst to give the 3-alkoxy-3,5-diene which is treated with a Vilsmeier reagent then rapidly hydrolysed to give the 6-formly deriv. This is a catalytically hydrolysed in presence of cyclohexene in ethanol/acetic acid to give 6alpha-methyl-9alpha-fluoro-11beta, 17alpha-dihydroxyprogesterone, which is dehydrogenated chemically or biologically to give fluorometholone. The product is an antiinflammatory steroid used in dermatology and ophthalmology. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2246359-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010122096-A1 |
| priorityDate | 1973-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.