http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2173693-A1

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filingDate 1972-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1973-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber FR-2173693-A1
titleOfInvention Recovering pure glycofrangulins - from rhamnus frangula by selective solvent extraction
abstract Process for recovering glycofrangulins from crude plant material, esp. the dried bark of the alder buckthorn (Rhamnus frangula L.) comprises extracting the material with a solvent mixt. of (i) a 1-3C alcohol and (ii) a 3-6C aliphatic or cyclic oxo and/or oxido cpd.; removing impurities from the extract by adsorption onto an activated polyamide; treating the purified soln. with a non-aqueous, esp. methanolic, soln. of an alkali hydroxide to produce a salt which is then treated with an acid or ion-exchanger, and solvent removed from the final product in the usual manner. Extract is a mild laxative. Process gives a purer product (90-95% consisting of molecules having at least 2 sugar residues bound to emodin) than prior art processes. Extraction solvent has excellent selectivity; most of the impurities (which are foul smelling and cause undesirable side effects) are irreversibly bound to the polyamide, and the process is suitable for large scale operation.
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Total number of triples: 21.