| abstract |
Cpds. of formula: (where R is 1-4C alkyl, 2-4C alkenyl or aryl or aryl-(1-3C)-alkyl opt. ring substd. by 1-4C alkyl or alkoxy or halogen; A is NH2, mono- or di(1-6C alkyl) amino, mono- or di(1-4C hydroxylalkyl)-aminon, pyrrolidino, piperidino, morpholino or piperazino 4-substd. by 1-4C alkyl, 2-hydroxyethyl, 2-(hydroxyethoxy)-ethyl or where R2 is 1-4C alkyl or alkoxy or halogen, and n = 0-3; R1 is H, halogen or 1-4C alkyl) have cardiac and circulatory activity. They may be prepd. by reacting MO-substd. coumarin (where M = H or a metal atom) with ACH2CHOHCH2Hal. |