| abstract |
Salicylamide ethers with analgesic, antiinflammatory and CNS-sedative activity. 2-OR-benzamides (in which R is PhCH2, p-Cl-C6H4-CH2-, ClCH2CH2-, piperidino-CH2CH2-, HOCH2CHOHCH2-, PhSO2(CH2)3-, (o-carbamoylphenoxy)-pentyl, CH3(CH2)8- or CH3(CH2)10-) are claimed. They are prepd. by reacting salicylamide with NaOEt, reacting the resulting sodio deriv. with R-halogen in ethanolic medium at or below the b.p. of EtOH, eliminating sodium halide and all or part of the EtOH, and crystallising the resulting title cpd. from an appropriate solvent. |