| abstract |
The invention relates to a process for the preparation of pharmacologically active benzonaphthalene derivatives of the formula <IMAGE> wherein: R1 is i) <IMAGE> or ii) -CH2OH -R6 is a radical <IMAGE> or a radical -OR7, wherein R7 is a hydrogen atom, alkyl radical, monohydroxyalkyl radical or polyhydroxyalkyl radical, r' and r" are each a hydrogen atom, lower alkyl radical, a mono or polyhydroxyalkyl radical, an optionally substituted aryl radical or a residue of an amino acid or an aminated sugar, or together form a heterocycle, R2 is a hydrogen atom, an alkyl radical, an alkoxy radical or a cycloaliphatic radical, R3 is a hydrogen atom, a hydroxyl radical, an alkyl radical, an alkoxy radical, an optionally substituted cycloaliphatic radical, a thiocycloaliphatic radical or a radical of the formula -O-Si(CH3)2-R8, wherein R8 is an alkyl radical, R4 and R5, identical or different, are a hydrogen atom, a lower alkyl radical, a hydroxy radical or a lower acyloxy radical, and the preparation of salts of benzonaphthalene derivatives of the aforementioned formula I. These compounds are useful in the topical and systemic treatment of dermatological, rheumatic, respiratory and ophthalmic illnesses. |