| abstract |
DIFLUORKETONIC PEPTIDES, OF FORMULA IA, IB OR IC, WHOSE SUBSTITUTES ARE AS SPECIFIED IN THE DESCRIPTION, AND WHICH INCLUDES THE DECOMPOSITION OF THE CORRESPONDING ESTER OF CARBOXYL ACID OF FORMULA IA, IB OR IC IN THE CABOX GROUP R3 ARE IN THE FORM OF THEIR ESTERS (6-12C) ARYL (7-13C) ARALKYL OR (1-6C) ALKYL, SUCH DECOMPOSITION TAKING PLACE BY BASE-CATALYZED HYDROLYSIS FOLLOWED BY THE ACIDIFICATION OF THE SALT OF THE BASE FORMED INITIALLY, IN THE SINUS OF A SUITABLE SOLVENT OR THINNER AND AT A TEMPERATURE OF 0-35GC: AFTER WHICH, IF A PHARMACEUTICALLY ACCEPTABLE SALT IS DESIRED, THIS CAN BE OBTAINED BY REACTION OF THE FORMULA I COMPOUND WITH THE APPROPRIATE BASE THAT IS APPROPRIATE WITH THE APPROPRIATE ACIL PHYSIOLOGICALLY ACCEPTABLE CATION. *FORMULA* |