| abstract |
DIFLUORKETONIC PEPTIDES (I), (II) AND (III), WHERE NOT EXCLUSIVELY, R1 IS C1-5 ALKYL, R2 C1-6 ALKYL SUBSTITUTE BY AMINO, HYDROXY OR ARYL CONTAINING C6, C10 OR C12, R3 C1-12 ALKYL , AND OPTIONALLY FROM 1 TO 4 HETEROATOMES, A IS CETO, AMIDO, ESTER, RA IS RB.NRC.CO WITH R3 C1-10 ALKYL, RC HYDROGEN OR METHYL; THEY ARE OBTAINED BY REACTING A DIFLUORATED AMINO CETO ACID (IV) WHERE Q IS A GROUP (V), WITH AN AMINE RB.NH.RC BY COUPLING WITH CARBODIIMIDE SOLUBLE IN NORMALIZED WATER U 1-HYDROXIBENZOTRIA AND ADHEDROFURYTRAYETHRIAZOLE SUCH AS HYDROXYBENZOTRIAZOLE 0 35GC. ARE INHIBITORS OF HUMAN LEUKOCYTE ELASTASE (HLE) APPLICABLE TO THE TREATMENT OF PULMONARY EMPHYSEMA, ATHEROSCLEROSIS, RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS. * FORMULA * N |