abstract |
THE ARYL SUBSTITUTED DERIVATIVES OF PRIRIDINE OR QUINOLINE (I), WHERE, NOT EXCLUSIVELY, X IS OXYGEN OR SULFUR, R1 AND R2 ARE C1-8 ALKYL, R3, R4, R5 AND R6, HALOGEN, CYANO OR NITRO, R5 AND R6 MAY FORM AN AROMATIC RING FUSED WITH THE PYRIDIL; THEY ARE OBTAINED BY REACTING A COMPOUND (II) WITH ANOTHER R2Y, BEING AND <<A GROUP OF GOOD OUTPUT>> SUCH AS HALOGEN OR ALKYL-, AND SUBSEQUENTLY WITH ANOTHER COMPOUND R1Y, IN AN INERT SOLVENT SUCH AS DIMETHYLPROMAMIDE, IN THE PRESENCE OF A OPTIONAL BASE POTASSIUM CARBONATE AND BETWEEN ROOM TEMPERATURE AND REFLUX TEMPERATURE. THEY INHIBIT 5-LIPOXIGENASE, SO IT IS APPLICABLE TO THE THERAPY OF ASTHMA, ALLERGY, RHEUMATIC ARTHRITIS, ARTHEROESCLEROSIS, PSORIASIS AND OTHER INFLAMMATORY SITUATIONS. *FORMULA* |