abstract |
PROCEDURE TO PREPARE AN ANTHRACICLINONE OF FORMULA (I), WHERE R IS HYDROGEN OR A HYDROXYL PROTECTIVE GROUP, IN WHICH A TETRALINE OF GENERAL FORMULA (II) IS OXIDIZED IN THE AROMATIC RING, WHERE R1 AND R2 ARE AN ATOME OR OF HALOGEN OR GROUP OCH3, BEING AT LEAST ONE OF THE TWO GROUP OCH3 AND R3 IS A HYDROGEN ATOM OR GROUP OR '', R '' BEING HYDROGEN OR A PROTECTIVE GROUP OF HYDROXYL; THE OXIDATION IS CARRIED OUT WITH AN AQUEOUS SOLUTION OF AMMONIUM NITRATE AND CERIUM AS THE OXIDIZING AGENT AND WITH THE TETRALINE DISSOLVED IN ACETONITRILE, THE REACTION MEDIUM IS SHAKED FOR ABOUT 10 MINUTES, OBTAINING A QUINONE THAT, DISSOLVES IN SILENCE REACTION OF DIELS-ALDER BY REACTING IT WITH A DIACETILE-DIHYDROXIBENZOCICLOBUTENO AT REFLUX TEMPERATURE FOR ABOUT 3 HOURS. IT HAS PHARMACOLOGICAL APPLICATION. *FORMULA* |