abstract |
DIHYDROPYRIDINES (I), WHERE NOT EXCLUSIVELY, R1 AND R2 ARE ALKYL, ALKYLENE OR ALCOXYALKYL UP TO C6 AND R3 AND R4 ARE C1-6 ALKYL, AR IS PHENYL, NAPHYTHL OR A HETEROCICLE OF 5 OR 6 MEMBERS, X-X S-, AND ALKYLENE OR ALKYLENE C2-12, P 0 O 1 AND THE BENZENE RING A MAY BE INSTITUTED OR REPLACED BY CYAN, NITRO O = NON =; THEY ARE OBTAINED BY REACTIONING A COMPOUND (II) WITH AN AMINE H2NCH2 CHOH (CH2O) P-AR, IN A SUITABLE SOLVENT UNTIL REFLUX TEMPERATURE. THEY HAVE BETA-ADRENERGIC BLOCKING ACTIVITY AND / OR CALCIUM SLOW CHANNEL BLOCKING SO THEY ARE APPLICABLE IN THE TREATMENT OF HEART DISEASES LIKE ANGINA; ALSO WITHOUT HYPERTENSORS. * FORMULA * O |