abstract |
PROCEDURE FOR THE PREPARATION OF FENETHANOLAMINE DERIVATIVES OF FORMULA (I), WHERE R IS A HYDROGEN OR A C1-3 ALKYL GROUP OF LINEAR CHAIN AND N IS 1 OR 3, AND ITS SALTS OF ADDITION OF PHYSIOLOGICALLY ACCEPTABLE, METABYL AND ESSENTIAL ACIDS , IN WHICH THE AMINATION OF A COMPOUND (II) IS PRODUCED, WHERE N IS INDICATED, R2, R3, R4 AND R5 ARE A HYDROGEN ATOM OR A PROTECTIVE GROUP AND R8 A CARBOXYL ACID GROUP OR A SALT OR A REACTIVE DERIVATIVE OF THE SAME, WITH AN AMINE RNH2, R IS DEFINED, IN THE PRESENCE OF AN ALCOHOL, AN ETHER OR A HALOGENATED HYDROCARBON AS SOLVENTS AND OF A CATALYST, BETWEEN 0GC AND 150GC; IF NECESSARY, ANY PROTECTIVE GROUPS PRESENT ARE ELIMINATED. IT HAS APPLICATION IN THE TREATMENT OF HEART FAILURE, CARDIOGENIC SHOCK OR CARDIAC ISCHEMIA. *FORMULA* |