abstract |
PREPARATION OF NEW 2,3-DIHIDRO-1,4-OXAZEPIN-5 (4H) -NAS AROMATICAS AND THEIR ANALOGUES WITH SULFUR, OF FORMULA (I), WHERE A IS AN AROMATIC RING: BENZENE, NAPHTHALENE OR PYRIDINE; B AND E ARE THE SAME OR DIFFERENT AND MAY BE S U O; R IS H OR ALKYL, CYCLOALKYL, OR PHENYLALKYL, N IS 1, 2 O 3; Z IS -NR1R2, 1H-PIRAZOL-1-ILO OR 1H-IMIDAZOL-1-ILO AND R1 AND R2 MAY BE H, ALKYL, CYCLOALKYL, PHENYLALKYL, PIPERAZINYL, PYRROLIDYL, MORPHOLINYL, OR PIPERINESMEDIUM, AND SUSINTED INTERMEDIUM. THEY ARE OBTAINED BY HALOGENATION OF A PRECURSOR FOLLOWED BY NEUTRALIZATION, SULFURATION (CASE OF THIAZEPINES), CYANURATION, REACTION WITH PIRAZOLE, IMIDAZOLE OR SECONDARY AMINE, REDUCTION AND AMINATION. THEY ARE USED AS ANTIHISTAMINES AND ANTI-ALLERGICS. |