| abstract |
DERIVATIVES OF DIAMIDES SUBSTITUTED WITH 7-OXABICICLOHEPTANO AND ITS PROSTAGLANDIN ANALOGS (I), WHERE M, IS 0 TO 4, N, 1 TO 5, P IS 1 TO 4, Q IS 1 TO 12, QYA -CHFCHY OTHERS, R, CO2H, A COMPOUND (IV) AND OTHERS, R1 AND R2 HO LOWER ALKYL; THEY ARE OBTAINED BY REACTION OF A COMPOUND (I) WITH ANOTHER HNR4R5 WHERE, NOT EXCLUSIVELY, R4 AND R5 ARE HYDROXY, LOWER ALCOXY OR ARYL TO PROVIDE A DESIRED COMPOUND (I). PHARMACOLOGICALLY USEFUL AS CARDIOVASCULAR AGENTS AND IN PARTICULAR FOR THE TREATMENT OF THROMBOTIC DISEASE. |