abstract |
CINOLINE DERIVATIVES (I) ARE PREPARED BY REACTING A COMPOUND (II) WITH AN AMINE OF FORMULA NHRR9, BETWEEN C10JC AND THE BOILING TEMPERATURE OF THE SOLVENT, AFTER WHICH, TO THE OBTAINED COMPOUND (I) AN ACID IS ADDED PHARMACEUTICALLY ACCEPTABLE ANION. R3 IS AN AMIDE (III); R4 ESNH; R5, R6, R7 AND R8 ARE CHOSEN FROM HYDROGEN, C1-10 ALKYL, C2-10 ALKENYL AND OTHERS; A IS A GROUP OF CARBOXYL ACID OR ACID DERIVATIVE WITH AMINE-MOVABLE SUBSTITUTE NHRR9, WHERE R AND R9 CAN BE HYDROGEN (BUT NOT AT THE SAME TIME), C1-10 ALKYL, C3-10 ALKYL AND OTHERS. OF APPLICATION AS DEPRESSORS OF THE CENTRAL NERVOUS SYSTEM AND AS ANXYOLYTICS. |