abstract |
PROCEDURE FOR THE PRODUCTION OF ESTER DERIVATIVES OF CEPHALOSPORIN, OF GENERAL FORMULA (I), AND OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS. IT CONSISTS OF REACTING A COMPOUND OF GENERAL FORMULA (II), IN WHICH W IS ACETOXY, ACETOACETOXY, A HALOGEN OR A CARBAMOYLOXY; R1 IS A HYDROGEN ATOM OR LOWER ALKYL GROUP; AND R2 IS AN ALYCYCLIC ALKYL GROUP OF 3 TO 12 CARBON ATOMS UNUSTITUTED OR SUBSTITUTED WITH LOWER ALKYL, WITH 1- (2-DIMETHYLAMINOETHYL) -5-MERCAPTO-1H-TETRAZOLE, TAKING EFFECT OF THE REACTION IN THE SENE OF A DISSOLVE LIKE WATER, TETRAHYDROFURAN, ETHYL ACETATE, DIOXANE OR ACETONITRILE. OF APPLICATION IN THE TREATMENT OF INFECTIONS IN MAN AND ANIMALS. |