| abstract |
METHOD OF PREPARING PERHYDROTIAZEPINE DERIVATIVES. IT CONSISTS OF CONDENSING A COMPOUND OF FORMULA (II) WITH A COMPOUND OF FORMULA (III), IN THE PRESENCE OF A SOLVENT AND OF A BASE AND AT A TEMPERATURE INCLUDED BETWEEN C20 AND 100JC, TO OBTAIN PERHYDROTIAZEPINE DERIVATIVES WHERE A GRUPULA R1 (IS) ALKYL FROM C 1 TO 10, A CYCLOALKYL GROUP FROM C 3 TO 8, A CARBOCYCLIC ARYL GROUP FROM C 6 TO 14 IN THE RING AND OTHERS; R2, R3, R4 AND R5 ARE, INDEPENDENTLY OF EACH OTHER, ALKYL GROUPS FROM C 1 TO 10, CYCLOALKYL GROUPS FROM C 3 TO 8 AND OTHERS; A IS A DIRECT CARBON LINK AND OTHERS; B IS AN ALKYLENE OR ALKYLIDENE GROUP FROM C 1 TO 4 AND OTHERS; AND N IS 0, 1 OR 2. THEY ARE USED FOR THE TREATMENT OF HIGH BLOOD PRESSURE. |