abstract |
PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF AZETIDIONA, OF GENERAL FORMULA (I), AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS. IT CONSISTS OF REACTING A COMPOUND OF GENERAL FORMULA (II), IN WHICH R REPRESENTS A HYDROGEN ATOM OR A PROTECTIVE CARBOXY GROUP; R13 REPRESENTS A HYDROXY PROTECTION GROUP; AND R14 REPRESENTS A PHENYL GROUP OR AN ALKYL GROUP THAT HAS 1 TO 4 CARBON ATOMS, WITH A COMPOUND OF GENERAL FORMULA (III), IN WHICH R23 REPRESENTS A PROTECTIVE GROUP OF CARBOXI, IN THE PRESENCE OF A BASE THAT HAS A PKA GREATER THAN 20, IN AN APROTICAL SOLVENT AND AT A TEMPERATURE OF BETWEEN C20 AND 30 DEGREES. FOR APPLICATION IN THE TREATMENT OF BACTERIAL INFECTIONS. |