abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF IMIDAZO-1,5-APIRIDINA, OF FORMULA (I), OF ITS STEREOISOMERS OR ITS MIXTURES AND OF ITS PHYSIOLOGICALLY COMPATIBLE SALTS. IT INCLUDES THE REACTION OF A COMPOUND ANALOGUE TO THE FORMULA (I) THAT HAS AN ADDITIONAL CARBOXI GROUP IN POSITION 1 OR 3, WITH A DECARBOXYLATING AGENT, TO OBTAIN A FORMULA (I) COMPOUND, IN WHICH R1 AND R2 MAY BE VARIOUS TYPES OF RADICALS, YN VALE 1-3. DECARBOXYLATION IS CARRIED OUT IN THE PRESENCE OF AN ACID, SUCH AS HYDROCHLORIC ACID AT A TEMPERATURE BETWEEN AMBIENT AND 200JC. THESE COMPOUNDS HAVE APPLICATIONS FOR THE TREATMENT OF GYNECOMASTY AND BREAST CANCER. |