| abstract |
PROCEDURE FOR SYNTHESIS OF PYRO-HYDANTOIN COMPOUNDS. IT INCLUDES: A) REACTING METHYLENE TRICYCLE WITH A LOWER ALKYL LI REAGENT TO OBTAIN A; B) REACT A WITH CO2 IN THE PRESENCE OF ION H TO OBTAIN CARBOXYL ACID; C) ESTEARIFYING THE ACID, THROUGH REACTION WITH AN ALCANOL, TO OBTAIN A LOWER ALKYL ESTER; D) REACT THE ESTER WITH AN ALKALINE METALLIC ALCOHOLATE AND SUBMIT TO THE BISULPHATE REDUCTION REACTION, TO OBTAIN AN ALPHA-HYDROXY ESTER OF THE HO-B-A-COO TYPE; E) MAKING THE ESTER REACT WITH A HALOHENATOR TO OBTAIN THE ALPHA-HALO ESTER; F) MAKING IT REACT WITH THIOUREA, TO PRODUCE A SPIROTRICYCLE AMINOTIAZOLONE INTERMEDIARY; G) HYDROLIZE THE INTERMEDIARY BY REACTION WITH AN ALCOHOLIC OR ACIDIC SOLUTION TO FORM SPIROHYDRAUROIN. BEING A AND B, AROMATIC RINGS. THEY ARE USED FOR THE TREATMENT OF COMPLICATIONS OF DIABETES MELLITUS IN PEOPLE AND ANIMALS. |