abstract |
METHOD OF PREPARING OXINDOL DERIVATIVES. IT CONSISTS OF REACTING A HET-CO2R FORMULA COMPOUND WHERE R IS C 1 TO 3 ALKYL, WITH A AR-NH2 FORMULA COMPOUND, IN AN AROMATIC SOLVENT, AT THE SOLVENT REFLUX TEMPERATURE, UNTIL THE REACTION IS COMPLETELY COMPLETE , TO OBTAIN OXINDOL DERIVATIVES OF FORMULA HET-CONH-AR, WHERE HET IS A GROUP OF FORMULAS (I), (II) OR (III)), WHERE Z IS 0 OR METHYLENE; R1 IS PHENYL OR C 1 TO 3 ALKYL; R4 IS A SUBSTITUTE IN POSITIONS 5, 6 OR 7 SELECTED FROM ALCANOYL FROM C 2 TO 6, CYCLOALKANOYL FROM C 4 TO 6 AND OTHERS; AND AR IS PHENYL, FLUORPHENIL AND OTHERS. THEY HAVE PHARMACEUTICAL APPLICATIONS AS ANTI-INFLAMMATORY. |