| abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF PIRACINO 2K, 3K-3,4 PIRIDO 1,2-A INDOL. IT INCLUDES: A) SUBMITTING TO RENT, TO THE REQUIRED EXTENSION, THE COMPOUND OF FORMULA (II), IN A SOLVENT, SUCH AS DIOXANE, BETWEEN 15 AND 30JC, DURING 15 TO 30 HOURS. BEING: R1, H, HAL AND OTHERS; AND R2, LOWER ALKYL OF C 1 TO 3, O H; AND B) REDUCE THE PRODUCT OBTAINED IN A) WITH SODIUM BOROHYDRIDE, IN A LOWER ALCANOL, METHANOL, AS A SOLVENT, WITH A SMALL QUANTITY OF WATER, DURING 1 TO 5 HOURS AND BETWEEN 10 AND 30JC, TO OBTAIN A COMPOUND (I) OF FORMULA OR A RESPECTIVE THERAPEUTICALLY ACCEPTABLE ACID ADDITION SALT. BEING: E3 AND R4, LOWER ALKYL, LOWER ALKYL, LOWER ALKYL AND OTHERS. IT IS USED IN PHARMACOLOGY AS ANTIHYPERTENSIVE IN MAMMALS. |