abstract |
METHOD OF PREPARING NEW IMIDAZOLE PREPARATIONS. IT CONSISTS OF REACTING A COMPOUND OF FORMULA (II) WITH A COMPOUND OF FORMULA (III) AT A TEMPERATURE BETWEEN C10 AND 100JC FOR 20 MINUTES AND 100 HOURS, TO PRODUCE A COMPOUND OF FORMULA (IV), AND OXIDIZE THE COMPOUND OBTAINING AGT OXIDANT, IN A SOLVENT, AT TEMPERATURE BETWEEN 0JC AND AMBIENT, TO OBTAIN IMIDAZOLE DERIVATIVES OF FORMULA (I) WHERE R1 IS HO A METHYL GROUP; R2 IS H OR AN ALKYL GROUP FROM C 1 TO 6, AN ALKYL GROUP FROM C 2 TO 6 AND OTHERS; R4 IS H OR AN ALKYL GROUP FROM C 1 TO 6, ALKYL GROUPS FROM C 2 TO 6 AND OTHERS; R3 IS A CARBOXI GROUP; X, Y, Z ARE H AND OTHERS; AND N IS 0, 1 OR 2. THEY HAVE APPLICATIONS TO TREAT THROMBOTIC STATES. |