abstract |
PROCEDURE FOR THE PREPARATION OF FORMULA COMPOUNDS (I). CONSISTENT OF THE REACTION OF A COMPOUND OF FORMULA (II) WITH ANOTHER OF FORMULA (III), WHERE AR REPRESENTS TIENYL, FURILO, PIRIDYL OR A PHENYL GROUP, OPTIONALLY SUBSTITUTED; R IS A LINEAR OR BRANCHED ALKYL GROUP OF 1 TO 7 CARBON ATOMS; AND X1 AND X2 ARE NITROGEN AND CARBON; TO OBTAIN COMPOUND (I) AND ITS PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS. THE REACTION IS PROMOTED, PREFERABLY, METALLIZING THE COMPOUND (III) IN AN ALKALINE METAL AGENT SUCH AS SODIUM HYDRIDE OR SODIUM, POTASSIUM OR LITHIUM AMIDIDE. OF APPLICATION AGAINST ANGINA PECAST, HYPERTENSION AND DYSRHTHMIA. |