abstract |
PROCEDURE FOR THE PREPARATION OF NEW TRICYCLIC NITROGENATED DIONES. IT CONSISTS OF: A) REACTING A KETONE OF FORMULA (II) IN A SOLVENT FOR 48 HOURS AT ROOM TEMPERATURE, TO OBTAIN A STRUCTURAL DERIVATIVE OF FORMULA (III); B) CYCLING THE DERIVATIVE OF FORMULA (III) TO OBTAIN A CYCLIC AMIDE OF FORMULA (IV); C) SAPONING THE OBTAINED CYCLIC AMIDE BY HEATING IN THE PRESENCE OF A BASE, FOLLOWED BY ACIDULATION WITH A DILUTED ACID AQUEOUS SOLUTION; AND D) CONVERTING THE RESULTING CYCLIC AMIDO ACID INTO NEW TRICYCLIC NITROGENATED DIONES OF FORMULA (I) BY INTERNAL DEHYDRATION BY HEATING TO REFLUX IN THE PRESENCE OF A DEHYDRATING AGENT; WHERE X IS 0, 1, 2 OR 3 AND Y AND Z ARE INDEPENDENTLY 0 OR 1. |