| abstract |
PROCEDURE FOR PREPARING MONOBASIC DERIVATIVES OF DISOBUTAMIDE, OF FORMULA (I), AND ITS PHYSIOLOGICALLY COMPATIBLE ACID ADDITION SALTS. INCLUDES THE REACTION OF A COMPOUND OF FORMULA (II) WITH 1-(CHLOROACETYL)PIPERIDINE TO FORM A COMPOUND OF FORMULA (I) IN WHICH R2 AND R3 REPRESENT LOWER ALKYL, X AND Y MAY BE VARIOUS TYPES OF RADICALS, AND N IS VALUE 1 TO 3 THE REACTION IS CARRIED OUT IN N,N-DIMETHYLFORMAMIDE, IN THE PRESENCE OF SODIUM HYDRIDE, AT ROOM TEMPERATURE. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR ANTIARRYTHMIC ACTIVITY. |