abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF 3-NITRO-DIHIDROPIRIDINA, FORMULA (I), AND ITS PHYSIOLOGICALLY COMPATIBLE SALTS. IT CONSISTS IN THE REACTION OF TRANSESTERIFICATION OF THE COMPOUND OF FORMULA (I) IN WHICH X REPRESENTS OXYGEN OR SULFUR AND, R1, R2 AND R3 MAY BE SEVERAL TYPES OF RADICALS, WITH THE APPROPRIATE REAGENT IN EACH CASE, TO OBTAIN THE COMPOUND OF FORMULA I), IN WHICH R3 REPRESENTS OH, SH OR NH2. THE REACTION IS CARRIED OUT IN AN INERT SOLVENT, AT A TEMPERATURE INCLUDING BETWEEN 10JC AND 150JC. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR POSITIVE INOTHROP EFFECT ON THE CIRCULATORY SYSTEM. |