abstract |
PROCEDURE FOR OBTAINING BENZOIC ACID DERIVATIVES, FORMULA (I) AND ITS SALTS. IT INCLUDES THE ACILATION REACTION OF A COMPOUND OF FORMULA (II), OR ONE OF ITS SALTS, WITH A COMPOUND OF FORMULA R1COY, TO FORM A COMPOUND OF FORMULA (I), IN WHICH R1 REPRESENTS LOWER ALKYL, R2 IS PROTECTED CARBOXYL OR WITHOUT PROTECTING, X IS HALOGEN AND Y IS AN OUTGOING GROUP. THE REACTION IS CARRIED OUT IN AN INERT SOLVENT, IN THE PRESENCE OF A BASE, AT A TEMPERATURE BETWEEN 0JC AND THE BOILING TEMPERATURE OF THE REACTION MIXTURE. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS AS ANTIASMATIC AGENTS. |