abstract |
METHOD FOR PREPARING DERIVATIVES OF 1-PIPERAZIN-3-PHENYLINDANE. CONSISTING OF: REACTING A COMPOUND OF FORMULA (IV) WITH A COMPOUND OF FORMULA (V), IN AN INERT SOLVENT SUCH AS METHYL ETHYL KETONE OR ETHANOL, IN THE PRESENCE OF AN ALKALI METAL CARBONATE SUCH AS POTASSIUM CARBONATE, AT THE REFLUX TEMPERATURE OF THE REACTION MIXTURE, TO OBTAIN THE COMPOUNDS OF FORMULA (I). BEING: R1 F H, HALOGEN, METHOXY, METHYLTHIO AND OTHERS; NS 2-4; X IS O O S; Y IS O, CH2 O N-R2; R2 IS H, AN ALKYL GROUP 1 TO 6C OR OTHERS; Z IS -(CH2)N- OR OTHERS; N IS 2 O 3; U IS N O C; A IS HALOGEN OR OSO2R; AND R IS ALKYL OR ARYL. USABLE AS A DRUG IN THE TREATMENT OF HYPERTENSION AND CARDIOVASCULAR DISEASES. |