| abstract |
PREPARATION OF AROIL SUBSTITUTED DIHYDRO-1,4-THIAZINES, OF FORMULA (I), WHERE AR IS PYRIDYL, PHENYL SUBSTITUTED OR NOT WITH HALOGENS, HALO-ALKYL OF 1-4C, ALCOXY OF 1-4C OR CARBOXY-ALKYL OF 1- 4C, N IS 0, 1 OR 2, R1 IS H, 2-4C ALKYL OR AMINOALKYL AND R2 IS H, CARBOXY-1-4C ALKYL OR (1-4C)-ALKOXY-CARBONYL-1-4C ALKYL, AND ITS SALTS. THEY ARE PREPARED BY CYCLATION OF A COMPOUND OF FORMULA (II), WHERE AR IS ALREADY DEFINED, RA AND RB ARE 1-4C ALKYLS, R2K AND R2L ARE H OR H AND CARBOXY-1-4C ALKYL OR (1-4C)CARBONYALKOXY -ALKYL OF 1-4C, OR BY CONDENSATION OF A COMPOUND (III), WHERE AR, RA AND RB HAVE ALREADY BEEN DEFINED, WITH A COMPOUND (IV), WHERE HAL IS CL, BR OR I AND R2K AND R2L ARE ALREADY DEFINED. THEY ARE USED AS ANTIRHEUMATICS OF ENTERAL, PARENTERAL OR LOCAL ADMINISTRATION. |