| abstract |
PROCEDURE FOR THE OBTAINING OF DIAZEPINONES, OF FORMULA (I), OF ITS DIASTEREOISOMERS AND ENANTIOMERS AND OF THEIR SALTS OF ADDITION OF PHYSIOLOGICALLY COMPATIBLE ACIDS. IT INCLUDES THE REACTION OF ACILATION OF A TRICYCLIC COMPOUND, OF FORMULA (II), WITH A DERIVATIVE OF A CARBOXILIC ACID, OF FORMULA (III), TO FORM THE COMPOUND OF FORMULA (I), IN WHICH OUR REPRESENTS A LABIL GROUP, AND B , X, A1, A2, R1, R2 AND Z MAY BE SEVERAL TYPES OF RADICALS. THE REACTION IS CARRIED OUT IN THE PRESENCE OF AN INERT ORGANIC SOLVENT, IN THE PRESENCE OF AN ACID FIXER, AT A TEMPERATURE BETWEEN C25JC AND 130JC. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THE TREATMENT OF BRADICARDIA AND BRADIARRHYTHMIA AND AS SPASMOLITICS. |