abstract |
PROCEDURE FOR THE PREPARATION OF TETRAHIDRONAPHTHALENE DERIVATIVES OF GENERAL FORMULA (I). A COMPOUND OF FORMULA (II) IS REACTED WITH AN AMINE OF GENERAL FORMULA (III), BY COMMON METHODS IN THE PRESENCE OR ABSENCE OF AN INERT ORGANIC SOLVENT UNDER THE REACTION CONDITIONS AND AT TEMPERATURE BETWEEN 80 AND 120 JC, IN THE PRESENCE OF AN ACCEPTOR OF ACID, ALREADY AT ROOM TEMPERATURE. THE NEW COMPOUNDS OBTAINED IN THE FORM OF RACEMATES RESOLVES IN THEIR OPTICAL ANTIODES AND BECOMES ITS ACID ADDITION SALTS THAT POSSESS CALCIUM-ANTAGONIST ACTIVITY AND THEREFORE CAN BE USED FOR THE CONTROL OR PREVENTION OF ARGLYTHEMIA AND CHEST HYPERTENSION, IN THE FORM OF PHARMACEUTICAL PREPARATIONS. |