abstract |
PROCEDURE FOR THE PREPARATION OF NEW PENEM DERIVATIVES. IT CONSISTS OF REACTING A COMPOUND OF FORMULA (II) WITH A THIOL OF FORMULA R4-SH AND THEN, IF YOU WISH: A) TO ELIMINATE ANY RX-BLOCKING GROUP OF CARBOXYL AND / OR B) TO CONVERT THE PRODUCT INTO THE FREE ACID OR INTO A SALT PHARMACEUTICALLY ACCEPTABLE OR IN AN IN VIVO HYDROLYZABLE ESTER, HAVING OBTAINED PENEM DERIVATIVES OF FORMULA (I), WHERE ONE OF THE R1 AND R2 RADICALS REPRESENT H AND THE OTHER REPRESENTS A HETEROAROMATIC RING AND A FIVE-MEMBER GROUP OF FIVE RING3 R4 IS A HYDROCARBIL GROUP FROM C 1 TO 10 AND OTHERS. IT HAS PHARMACOLOGICAL APPLICATIONS BECAUSE IT IS USEFUL IN THE TREATMENT OF ANTIBACTERIAL INFECTIONS IN MAN OR ANIMALS. |