http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-8609277-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96f271da93cd6b6d31f0eda6f68d1aa2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 1985-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1986-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-8609277-A1 |
| titleOfInvention | PROCEDURE FOR THE OBTAINING OF 1- (BIS- (4-FLUOROFENIL) - METHYL) -4- (3-FENIL-2-PROPENIL) -HEXAHIDRO-1H-1, 4-DIACEPINA |
| abstract | PROCEDURE FOR THE PREPARATION OF 1-BIS- (4-FLUOROPHENYL) -METIL-4- (3-PHENYL-2-PROPENYL) -HEXAHYDRO-1H-1,4-DIACEPINE OF FORMULA (I), ITS SALTS WITH NON-TOXIC ACIDS , ESPECIALLY DICHLORHYDRATE, AND COMPOSITIONS CONTAINING THESE SUBSTANCES AS AN ACTIVE PRINCIPLE. 1-ETOXICARBONYL-HEXAHYDRO-1,4-DIACEPINE IS REACTED WITH CINAMYL CHLORIDE IN THE PRESENCE OF TRIETHYLAMINE, TO OBTAIN 1-ETOXYCARBONYL-4- (3-PHENYL-2-PROPENYL) -HEXAHYDRO-1,4-DIACEPINE FORMULA (III), WHICH, BY ALKALINE HYDROLYSIS IN ETHANOL, IS TRANSFORMED INTO 4- (3-PHENYL-2-PROPENYL) -1H-HEXAHYDRO-1,4-DIACEPINE OF FORMULA (IV), WHICH IN TURN IS REACTED WITH AN EQUIMOLAR AMOUNT OF BIS- (40FLUOROPHENYL) -CHLOROMETHANE IN THE PRESENCE OF TRIETHYLAMINE IN EXCESS TO GIVE THE 1-BIS- (4-FLUOROPHENYL) -METHYL-4- (3-PHENYL-2-PROPENYL) -HEXAHYDRO-1H-1, 4-DIACEPINE. THE COMPOUND IS INTENDED FOR THE TREATMENT OF DIVERSE CIRCULATORY DISORDERS. |
| priorityDate | 1984-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.